Therapeutic processes for eradicating cancerous or benign tumours by laser beams using the excitonic approach of peptide groups

Published: 30 June 2022
Abstract Views: 1173
PDF: 189
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The aim of the present study was to develop a protocol for the treatment of cancerous or benign tumours making use of laser rays, also demonstrating that the destruction process remains exclusively confined in the defective organ. Thermal effects of lasers on biological tissue have been elucidated using vibrational excitations approach of peptide groups (PGs). It was proposed a Hamiltonian which integrate excitations induced by laser pulses and it was shown that the system is governed by a nonlinear equation with strong nonlinearity. It was also exactly described what happens in polypeptide chain once the unwanted organ is irradiated by the Neodymium-doped yttrium aluminium garnet, chosen as incident laser. It was shown that, the advent of incident laser beams contributes to a sudden reinforcement of the vibrational excitations of PGs frequencies and amplitudes. It was also demonstrated that the heating process leads to transverse and longitudinal deformation of the polypeptide chain and these sudden changes lead to the denaturation and subsequently to the destruction of the bulky organ. The drawn curves make it possible to estimate the spatial expansion of the denaturation, in order to effectively control the spread of the heat. Laser irradiation leads to a drastic increase in the vibration amplitudes of the PGs and subsequently results in the destruction of the undesirable tissue. An appropriate choice of the laser can make it possible to circumscribe the destruction only in the defective zone and to protect healthy cells.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Schnelzer M, Hammer MGP, Kreuzer M, Tschense A, Grosche B. Accounting for Smoking in the Radon-related Lung Cancer Risk Among German Uranium Miners: Results of a Nested Case-control Study. Health Physics 2010; 98: pp. 20-28. DOI: https://doi.org/10.1097/HP.0b013e3181b8ce81
Mohammed H, Ismail EM, Mohan, Hicham DP, Mustapha HM. A Hybrid Gene Selection Strategy Based on Fisher and Ant Colony Optimization Algorithm for Breast Cancer Classification. iJOE 2021; 17: pp. 148-63. DOI: https://doi.org/10.3991/ijoe.v17i02.19889
Ahn S, Shin DO, Choi SH, Koo J, Lee SS, Park D, Oh Y, Park S, Kim DW.
Status and Perception of Risk Management in Radiation Therapy Survey Among Korean Medical Physicists. Health Physics 2018, 114; pp. 77-83. DOI: https://doi.org/10.1097/HP.0000000000000739
Asma F, Khadija FL, Jabran D, Said B, Said B, Fatima ZR, Hassane K. Contribution of Simulation in the Development of the Competences of Future Radiology Technicians in the Framework of the Management of the Risks Associated with the Medical Radiology Techniques. International Journal of Online and Biomedical Engineering 2021; 17: pp. 135-52. DOI: https://doi.org/10.3991/ijoe.v17i08.23779
Simo E. Therapeutic Processes to Overcome Angioma, Condyloma and Trachea tumours in the Frame work of the Numerical Analysis of Heat Transfer in Biological Tissues Irradiated by Pulsed Laser. Ed. Generis Publishing, 2021, ISBN: 9798598496664
Simo E, Caputo JG. High-order harmonic generation by double-photoionization accounting for the correlation between continuum electrons. Optik 2011; 122: pp. 247-55. Int. J. Light Electron Opt. DOI: https://doi.org/10.1016/j.ijleo.2009.11.030
Cruzeiro L. The Davydov/Scott Model for Energy Storage and Transport in Proteins. J. Biol Phys. 2009; 35(1): pp. 43-55. DOI: https://doi.org/10.1007/s10867-009-9129-0
Simo E, Kofane TC. On nonlinear Effects in Molecular Chains with one Type of Intramolecular Vibrations. Phys. Scipta 1994; 49: 543. DOI: https://doi.org/10.1088/0031-8949/49/5/006
Georgiev DD, Glazebrook JF. Thermal stability of solitons in protein α-helices. Chaos, Solitons and Fractals 2022; 155: 111644. DOI: https://doi.org/10.1016/j.chaos.2021.111644
Georgiev DD, Glazebrook JF. On the quantum dynamics of Davydov solitons in protein α-helices. Physica A: Statistical Mechanics and Its Applications 2019; 517: pp. 257-69. DOI: https://doi.org/10.1016/j.physa.2018.11.026
Georgiev DD, Glazebrook JF. Launching of Davydov solitons in protein alpha-helix spines. Physica E Low-dimensional Systems and Nanostructures 2020; 124: 114332 DOI: https://doi.org/10.1016/j.physe.2020.114332
Peyrard M. Nonlinear excitations in biomolecules. Springer-Verlag Berlin Heidelberg and Les Editions de Physique Les Ulis, 1995. DOI: https://doi.org/10.1007/978-3-662-08994-1
Manns F, Borja D, Parel JM, Smiddy W, Culbertson W. Semianalytical thermal model for sub ablative laser heating of homogeneous nonperfused biological tissue: application to laser thermokeratoplasty. Journal of Biomedical Optics 2003; 8: pp. 288-97. DOI: https://doi.org/10.1117/1.1560644
Tung MM, Lopez Molina JA, Rivera MJ, Berjano EJ. Modeling the heating of biological tissue based on the hyperbolic heat transfer equation. Mathematical and Computer Modelling 2009; 50(5-6): pp. 665-72. DOI: https://doi.org/10.1016/j.mcm.2008.12.023

How to Cite

Zambe, J. I. C., Simo, E., Kuicheu, D. K., Fono Fotso, P. R., & Abdel, H. S. (2022). Therapeutic processes for eradicating cancerous or benign tumours by laser beams using the excitonic approach of peptide groups. Laser Therapy, 29(1), 107–114. https://doi.org/10.4081/ltj.2022.297