https://doi.org/10.4081/ltj.2022.303 The effectiveness of flashlamp-pumped pulsed dye laser in conjunction with topical imiquimod treatment for rosacea PDF Vol. 29 No. 2 (2022) Published: 27 December 2022 Laser Therapy, pulsed dye lasers, imiquimod, rosacea, flashlamp-pumped Pulsed-Dye Laser (PDL) Abstract Views: 1602 PDF: 92 Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Authors Chen-Jen Chang chengjen@h.tmu.edu.tw Department of Plastic Surgery; Department of Plastic Surgery, School of Medicine, College of Medicine; Graduate Institute of Biomedical Optomechatronics; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, , Taiwan, Province of China. Yen-Chang Hsiao Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan, Province of China. Ana Elena Aviña Department of Plastic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Province of China. Yu-Fan Chiang Medical School, University of Queensland, Australia. Abstract Rosacea is a chronic dermatosis with no cure. Our goal was to evaluate if the combination of flashlamp-pumped Pulsed Dye Laser (PDL) treatment with topical imiquimod could improve therapeutic outcomes. Fourty patients diagnosed with rosacea and aged between 16 and 53 years were assigned for three different types of treatment: i) PDL-only, ii) imiquimod-only, and iii) PDL + imiquimod. The PDL test sites received a single treatment with the VBeam laser (λ = 595 nm; spot size = 7 mm; tp = 1500 msec) at a dosage of 10 J/cm2 with cryogen spurt duration (30 msec) and the delay time (20 msec). For the test sites of PDL + imiquimod and imiquimod-only, the patients applied imiquimod topically to the test sites once a day for 1 month. Patients were followed-up at 1, 3, and 6 months. The primary efficacy was measured with a DermoSpectrometer. Patients were also monitored for adverse effects. Pair-wise analysis showed statistically significant differences between the blanching responses for the PDL + imiquimod and PDL-only and imiquimod-only treatments (p<0.005). Transient hyperpigmentation was noted in 5% (n=2) and 20% (n=8) of patients in the PDL + imiquimod and PDL-only treatment, respectively. Hyperpigmentation resolved spontaneously within 6 months. Permanent hypopigmentation or scarring was not observed. Superior blanching responses were obtained when using PDL + imiquimod than PDL-only or imiquimod-only treatment for rosacea. A larger number of patients are required to support the results of this study. Metrics Dimensions Altmetric PlumX Metrics Downloads Download data is not yet available. Citations References Wilkin J, Dahl M, Detmar M, et al. Standard classification of rosacea: Report of the national rosacea society expert committee on the classification and staging of rosacea. J Am Acad Dermatol 2002;46:584. DOI: https://doi.org/10.1067/mjd.2002.120625 Odom R, Dahl M, Dover J, et al. Standard management options for rosacea, part 2: options according to subtype. Cutis 2009;84:97. Taub AF, Devita EC. 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DOI: https://doi.org/10.1016/j.jaad.2003.05.005 Glaich AS, Friedman PM, Jih MH, Treatment of inflammatory facial acne vulgaris with combination 595-nm pulsed-dye laser with dynamic-cooling-device and 1,450-nm diode laser. Lasers Surg Med 2006;38:177-80 DOI: https://doi.org/10.1002/lsm.20209 Citation / Copyright How to Cite Chang, C.-J., Hsiao, Y.-C., Aviña, A. E., & Chiang, Y.-F. (2022). The effectiveness of flashlamp-pumped pulsed dye laser in conjunction with topical imiquimod treatment for rosacea. Laser Therapy, 29(2). https://doi.org/10.4081/ltj.2022.303 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published. 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