https://doi.org/10.4081/ltj.2023.325 Monitoring the effectiveness of nanosecond laser for the treatment of port-wine stain patients using non-invasive imaging systems PDF Vol. 30 No. 2 (2023) Submitted: 6 September 2023 Accepted: 23 October 2023 Published: 16 November 2023 Laser therapy, port-wine stains, spectrophotometry, thermography Abstract Views: 3526 PDF: 62 Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Authors Cheng-Han Jhan https://orcid.org/0009-0006-0805-2069 Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan, Province of China. Ana Elena Aviña d142111012@tmu.edu.tw https://orcid.org/0000-0001-6443-0200 International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taiwan; Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Province of China. Tzu-Sen Yang https://orcid.org/0000-0003-0287-3916 Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan, Province of China. Yu-Fan Chiang Medical School, University of Queensland, Brisbane, Australia. Cheng-Jen Chang https://orcid.org/0000-0001-5481-581X Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan; Department of Plastic Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan, Province of China. Abstract A variety of lasers have been used to treat port-wine stain (PWS) birthmarks, however, all of them carry the risk of adverse effects. Our objective was to assess the effectiveness and safety of nanosecond (ns) laser treatment for PWS patients using non-invasive images. This study included 20 PWS patients, whose ages ranged from one to sixteen years. A nanosecond laser (λ=595 nm; τp=2 ns), with a spot size of 5 mm, and parameters of 0.2-0.3 J/cm2, 5 Hz, was used in three passes. The infrared thermal imager aided in determining the optimal laser dosage and preventing side effects. The primary efficiency was evaluated using a DermaSpectrometer, and patients were followed up after one week, four weeks, three months, and twelve months. The infrared thermal images of skin surface temperature assessment in the first ten seconds were recorded after the maximal energy density 0.3 J/cm2 treatment. The thermal wave equation and Penne’s bioheat transfer equation ranged from 32.4±0.1 to 33.8±0.2°C, 32.6±0.1 to 34.7±0.3°C (baseline skin surface temperature - 32.4±0.3°C) respectively. Transient hyperpigmentation appeared in 5% (n=1) of the 20 patients, but it resolved spontaneously within three months. There was no evidence of permanent hypopigmentation or scarring. 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DOI: https://doi.org/10.1097/DSS.0000000000000723 Author Biography Cheng-Jen Chang, Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan; Department of Plastic Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei Citation / Copyright How to Cite Jhan, C.-H., Aviña, A. E., Yang, T.-S., Chiang, Y.-F., & Chang, C.-J. (2023). Monitoring the effectiveness of nanosecond laser for the treatment of port-wine stain patients using non-invasive imaging systems. 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