Light-Emitting-Diode photochemical effects in dentistry: an overview

Published: 30 January 2024
Abstract Views: 1788
PDF: 59
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

This work aims to show the important role that might be played by the daily utilization of LED technology in dentistry, as well as to suggest the advantages of the application of Light-Emitting-Diode (LED) Photobiomodulation (PBM) and PhotoDynamic Therapy (PDT) for the treatment of a large number of oral diseases. It presents an overview of the most recent and interesting studies on PBM and PDT by LED light in periodontics, endodontics, orthodontics, implantology, and Oral Medicine. LED light utilization offers several advantages compared to Laser: the possibility to treat large surfaces, low cost, and safety for patients and operators. The use of LED in dentistry may represent a great help for treating a large number of diseases with low costs and without side effects.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Mester A, Mester A. The History of Photobiomodulation: Endre Mester (1903–1984). Photomed Laser Surg 2017;35:393-4. DOI: https://doi.org/10.1089/pho.2017.4332
Mester E, Kore'nyi-Both A, Spiry T, et al. Stimulation of wound healing by means of laser rays. Acta Chir Acad Sci Hung 1973;14:347–56.
Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B 1999;49:1-17. DOI: https://doi.org/10.1016/S1011-1344(98)00219-X
Hamblin MRH, Demidova TN. Mechanisms of low level light therapy. Proc SPIE 6140 Mech Low-Light Ther 2006;614001. DOI: https://doi.org/10.1117/12.646294
Kubackla J, Choromańska A, Rossowska J, et al. Cell Membrane Transport Mechanisms: Ion Channels and Electrical Properties of Cell Membranes. Adv Anat Embryol Cell Biol 2017;227:39-58. DOI: https://doi.org/10.1007/978-3-319-56895-9_3
Chung H, Dai T, Sharma SK, et al. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng 2012;40:516-33. DOI: https://doi.org/10.1007/s10439-011-0454-7
Anders JJ, Arany PR, Baxter GD, Lanzafame RJ. Light-Emitting Diode Therapy and Low-Level Light Therapy Are Photobiomodulation Therapy. Photobiomodul Photomed Laser Surg 2019;37:63-65. DOI: https://doi.org/10.1089/photob.2018.4600
Heiskanen V, Hamblin MR. Photobiomodulation: lasers vs. light emitting diodes? Photochem Photobiol Sci 2018;17:1003-17. Erratum in: Photochem Photobiol Sci 2018;18:259. DOI: https://doi.org/10.1039/c8pp00176f
Bekmukhametova A, Ruprai H, Hook JM, et al. Photodynamic therapy with nanoparticles to combat microbial infection and resistance. Nanoscale 2020;12:21034-59. DOI: https://doi.org/10.1039/D0NR04540C
Hu X, Huang YY, Wang Y, et al. Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections. Front Microbiol 2018;9:1299. DOI: https://doi.org/10.3389/fmicb.2018.01299
Merigo E, Conti S, Ciociola T, et al. Effect of different wavelengths and dyes on Candida albicans: In vivo study using Galleria mellonella as an experimental model. Photodiagnosis Photodyn Ther 2017;18:34-8. DOI: https://doi.org/10.1016/j.pdpdt.2017.01.181
Merigo E, Conti S, Ciociola T, et al. Antimicrobial Photodynamic Therapy Protocols on Streptococcus mutans with Different Combinations of Wavelengths and Photosensitizing Dyes. Bioengineering (Basel) 2019;6:42. DOI: https://doi.org/10.3390/bioengineering6020042
Merigo E, Chevalier M, Conti S, et al. Antimicrobial effect on Candida albicans biofilm by application of different wavelengths and dyes and the synthetic killer decapeptide KP. Laser Ther 2019;28:180-6. DOI: https://doi.org/10.5978/islsm.28_19-OR-14
de Sousa AP, Santos JN, Dos Reis JA Jr, et al. Effect of LED phototherapy of three distinct wavelengths on fibroblasts on wound healing: a histological study in a rodent model. Photomed Laser Surg 2010;28:547-52. DOI: https://doi.org/10.1089/pho.2009.2605
Enwemeka CS. Antimicrobial blue light: an emerging alternative to antibiotics. Photomed Laser Surg 2013;31:509-11. DOI: https://doi.org/10.1089/pho.2013.9871
Zupin L, Gratton R, Fontana F, et al. Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells. J Biophotonics 2021;14:e202000496. DOI: https://doi.org/10.1002/jbio.202000496
Mills RW, Jandt KD, Ashworth SH. Dental composite depth of cure with halogen and blue light emitting diode technology. Br Dent J 1999;186:388-91. DOI: https://doi.org/10.1038/sj.bdj.4800120a
Michida SM, Passos SP, Marimoto AR, et al. Intrapulpal temperature variation during bleaching with various activation mechanisms. J Appl Oral Sci 2009;17:436-9. DOI: https://doi.org/10.1590/S1678-77572009000500016
da Fonseca EV, Bussadori SK, da Silva Martinho LFC, et al. Evaluation of photobiomodulation effects on pain, edema, paresthesia, and bone regeneration after surgically assisted rapid maxillary expansion: Study protocol for a randomized, controlled, and double-blind clinical trial. Medicine (Baltimore) 2019;98:e17756. DOI: https://doi.org/10.1097/MD.0000000000017756
Rosa CB, Habib FA, de Araújo TM, et al. Effect of the laser and light-emitting diode (LED) phototherapy on midpalatal suture bone formation after rapid maxilla expansion: a Raman spectroscopy analysis. Lasers Med Sci 2014;29:859-67. DOI: https://doi.org/10.1007/s10103-013-1284-7
Caccianiga G, Caccianiga P, Baldoni M, et al. Pain Reduction during Rapid Palatal Expansion Due to LED Photobiomodulation Irradiation: A Randomized Clinical Trial. Life (Basel) 2021;12:37. DOI: https://doi.org/10.3390/life12010037
Ekizer A, Uysal T, Güray E, Yüksel Y. Light-emitting diode photobiomodulation: effect on bone formation in orthopedically expanded suture in rats--early bone changes. Lasers Med Sci 2013;28:1263-70. DOI: https://doi.org/10.1007/s10103-012-1214-0
Ekizer A, Uysal T, Güray E, Akkuş D. Effect of LED-mediated-photobiomodulation therapy on orthodontic tooth movement and root resorption in rats. Lasers Med Sci 2015;30:779-85. DOI: https://doi.org/10.1007/s10103-013-1405-3
Uysal T, Ekizer A, Akcay H, et al. Resonance frequency analysis of orthodontic miniscrews subjected to light-emitting diode photobiomodulation therapy. Eur J Orthod 2012;34:44-51. DOI: https://doi.org/10.1093/ejo/cjq166
Shaughnessy T, Kantarci A, Kau CH, et al. Intraoral photobiomodulation-induced orthodontic tooth alignment: a preliminary study. BMC Oral Health 2016;16:3. DOI: https://doi.org/10.1186/s12903-015-0159-7
Levrini L, Carganico A, Deppieri A, et al. Predictability of Invisalign® Clear Aligners Using OrthoPulse®: A Retrospective Study. Dent J (Basel) 2022;10:229. DOI: https://doi.org/10.3390/dj10120229
Güray Y, Yüksel AS. Effect of light-emitting photobiomodulation therapy on the rate of orthodontic tooth movement: A randomized controlled clinical trial. J Orofac Orthop 2023;84:186-99. DOI: https://doi.org/10.1007/s00056-022-00425-3
Costa DR, Pessoa DR, Seefeldt VB, et al. Orofacial evaluation of individuals with temporomandibular disorder after LED therapy associated or not of occlusal splint: a randomized double-blind controlled clinical study. Lasers Med Sci 2021;36:1681-9. DOI: https://doi.org/10.1007/s10103-021-03269-2
de Sousa DFM, Malavazzi TCDS, Deana AM, et al. Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial. Lasers Med Sci 2022;37:3423-31. DOI: https://doi.org/10.1007/s10103-022-03600-5
Al-Quisi AF, Jamil FA, Abdulhadi BN, Muhsen SJ. The reliability of using light therapy compared with LASER in pain reduction of temporomandibular disorders: a randomized controlled trial. BMC Oral Health 2023;23:91. DOI: https://doi.org/10.1186/s12903-023-02784-8
Kalhori KAM, Vahdatinia F, Jamalpour MR, et al. Photobiomodulation in Oral Medicine. Photobiomodul Photomed Laser Surg 2019;37:837-61. DOI: https://doi.org/10.1089/photob.2019.4706
Merigo E, Rocca JP, Pinheiro ALB, Fornaini C. Photobiomodulation Therapy in Oral Medicine: A Guide for the Practitioner with Focus on New Possible Protocols. Photobiomodul Photomed Laser Surg 2019;37:669-80. DOI: https://doi.org/10.1089/photob.2019.4624
de Carvalho FB, Andrade AS, Rasquin LC, et al. Effect of Laser (λ 660 nm) and LED (λ 630 nm) photobiomodulation on formocresol-induced oral ulcers: a clinical and histological study on rodents. Lasers Med Sci 2015;30:389-96. DOI: https://doi.org/10.1007/s10103-014-1680-7
Freire Mdo R, Freitas R, Colombo F, et al. LED and laser photobiomodulation in the prevention and treatment of oral mucositis: experimental study in hamsters. Clin Oral Investig 2014;18:1005-13. DOI: https://doi.org/10.1007/s00784-013-1058-4
de Cássia Dias Viana Andrade R, Azevedo Reis T, Rosa LP, de Oliveira Santos GP, da Cristina Silva F. Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect. Support Care Cancer 2022;30:7365-71. DOI: https://doi.org/10.1007/s00520-022-07127-x
Gokmenoglu C, Ozmeric N, Erguder I, Elgun S. The effect of light-emitting diode photobiomodulation on implant stability and biochemical markers in peri-implant crevicular fluid. Photomed Laser Surg 2014;32:138-45. DOI: https://doi.org/10.1089/pho.2012.3473
Kashefimehr A, Rahbar M, Faramarzi M, et al. Effect of Light Emitting Diode Photobiomodulation on the Stability of Dental Implants in Bone Grafted Cases: a Split-Mouth Randomized Clinical Trial. Maedica (Bucur) 2021;16:223-9.
Dalapria V, Marcos RL, Bussadori SK, et al. LED photobiomodulation therapy combined with biomaterial as a scaffold promotes better bone quality in the dental alveolus in an experimental extraction model. Lasers Med Sci 2022;37:1583-92. DOI: https://doi.org/10.1007/s10103-021-03407-w
Foletti JM, Remy F, Chevenement L, et al. Effect of LED photobiomodulation on dental implant osseointegration: An in vivo study. J Dent Res Dent Clin Dent Prospects 2023;17:28-34. DOI: https://doi.org/10.34172/joddd.2023.36954
Serrage HJ, Cooper PR, Palin WM, et al. Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens. Lasers Med Sci 2021;36:1957-69. DOI: https://doi.org/10.1007/s10103-021-03331-z
Lee J, Song HY, Ahn SH, et al. In vitro investigation of the antibacterial and anti-inflammatory effects of LED irradiation. J Periodontal Implant Sci 2023;53:110-9. DOI: https://doi.org/10.5051/jpis.2200920046
Mongardini C, Di Tanna GL, Pilloni A. Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial. Lasers Med Sci 2014;29:1-8. DOI: https://doi.org/10.1007/s10103-012-1225-x
Cho K, Lee SY, Chang BS, et al. The effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans attached to surface-modified titanium. J Periodontal Implant Sci 2015;45:38-45. DOI: https://doi.org/10.5051/jpis.2015.45.2.38
Park D, Choi EJ, Weon KY, et al. Non-Invasive Photodynamic Therapy against -Periodontitis-causing Bacteria. Sci Rep 2019;9:8248. DOI: https://doi.org/10.1038/s41598-019-44498-4
Asnaashari M, Mojahedi SM, Asadi Z, et al. A comparison of the antibacterial activity of the two methods of photodynamic therapy (using diode laser 810 nm and LED lamp 630 nm) against Enterococcus faecalis in extracted human anterior teeth. Photodiagnosis Photodyn Ther 2016;13:233-7. DOI: https://doi.org/10.1016/j.pdpdt.2015.07.171
Asnaashari M, Ashraf H, Rahmati A, Amini N. A comparison between effect of photodynamic therapy by LED and calcium hydroxide therapy for root canal disinfection against Enterococcus faecalis: A randomized controlled trial. Photodiagnosis Photodyn Ther 2017;17:226-32. DOI: https://doi.org/10.1016/j.pdpdt.2016.12.009
Mozayeni MA, Vatandoost F, Asnaashari M, et al. Comparing the Efficacy of Toluidine Blue, Methylene Blue and Curcumin in Photodynamic Therapy Against Enterococcus faecalis. J Lasers Med Sci 2020;11:S49-54. DOI: https://doi.org/10.34172/jlms.2020.S8
Shahbazi S, Esmaeili S, Feli M, Asnaashari M. Photodynamic Therapy in Root Canal Disinfection: A Case Series and Mini-Review. J Lasers Med Sci 2022;13:e19. DOI: https://doi.org/10.34172/jlms.2022.19
Sulewska M, Duraj E, Sobaniec S, et al. A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: A case series. Photodiagnosis Photodyn Ther 2019;25:50-7. DOI: https://doi.org/10.1016/j.pdpdt.2018.11.009
Di Stasio D, Romano A, Russo D, et al. Photodynamic therapy using topical toluidine blue for the treatment of oral leukoplakia: A prospective case series. Photodiagnosis Photodyn Ther 2020;31:101888. DOI: https://doi.org/10.1016/j.pdpdt.2020.101888

How to Cite

Fornaini, C., Wang, H., Li, Y., & Rocca, J. P. (2024). Light-Emitting-Diode photochemical effects in dentistry: an overview. Laser Therapy, 31(1). https://doi.org/10.4081/ltj.2024.377