Original Research Articles
Vol. 31 No. 2 (2024)
Effectiveness of photobiomodulation and resistive exercise on cartilage tissue in osteoarthritic rats
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 3 May 2024
Accepted: 4 July 2024
Accepted: 4 July 2024
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The aim of the present study was to investigate the association of a resistive training and Photobiomodulation (PBM) on cartilage tissue in an experimental model of knee Osteoarthritis (OA). Forty male Wistar rats (weigh, ± 150g) were distributed into 4 groups. Treatments were performed for 8 weeks (3 sessions per week). The specimens were evaluated by histology, OARSI, morphometric and immunohistochemistry analysis. The results showed that the interventions were able to modulate the degenerative process reacted to OA. Exercised animals (with or without PBM) demonstrated lower values for OARSI and lower expression of IL-1β, caspase-3, MMP-13. Furthermore, animals treated with the associated treatments presented significantly decrease in the density of chondrocytes. Resistive exercise training modulated the morphological alterations and inflammatory process related to the OA progression. However, PBM isolated have not produced extra effects on the variables evaluated.
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Ethics Approval
The Research Ethics Committee on Animal of the Federal University of São Carlos (814715/2013) approved this study and all the national guidelines for the use of laboratory animals were observed.CRediT authorship contribution
Luiz Henrique Gomes Santos, Lívia Assis, Ana Claudia Rennó: conceptualization, design; Carla Roberta Tim, Luiz Henrique Gomes Santos, Thatiane Izabele Ribeiro Santos, Mirian Bonifácio Silva, Cintia Cristina Santi Martignago: data acquisition; Fernando Vasilceac, Mariane Santos Trevisan, Daniel Araki Ribeiro, Nivaldo Antonio Parizotto, Daniel Araki Ribeiro, Ana Claudia Rennó: data analysis and interpretation; Luiz Henrique Gomes Santos, Lívia Assis, Daniel Araki Ribeiro, Nivaldo Antonio Parizotto, Ana Claudia Rennó: writing – original draft, critical revision for relevant intellectual content. All authors gave the final approval of the version to be submitted and agreed to be accountable for all aspects of the work.
Data Availability Statement
All data generated or analyzed during this study are included in this published article.
How to Cite
Gomes Santos, L. H., Assis, L., Tim, C. R., Ribeiro Santos, T. I., Santi Martignago, C. C., Bonifácio Silva, M., Vasilceac, F., Santos Trevisan, M., Araki Ribeiro, D., Lopes Cunha, L. C., Parizotto, N. A., & Rennó, A. C. (2024). Effectiveness of photobiomodulation and resistive exercise on cartilage tissue in osteoarthritic rats. Laser Therapy, 31(2). https://doi.org/10.4081/ltj.2024.401
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