Original Research Articles
Vol. 32 No. 2 (2025)
https://doi.org/10.4081/ltj.2025.417

Evaluation of eyelid dermal thickening following EndoliftX® treatment with a 1470 nm diode laser: assessment using a high-frequency linear ultrasound probe

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Published: 15 December 2025
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Interstitial laser therapy, skin laxity, periorbital region

Authors

Gloria Misasi
Department of Aesthetic Surgery, Niccolò Cusano University, Rome, Italy.
Roberto Ruffa
studioruffa@gmail.com
https://orcid.org/0009-0003-1216-5531
Department of Aesthetic Medicine, UniCamillus University, Rome, Italy.

This study examines the impact of EndoliftX® 1470 nm diode laser treatment (Eufoton®, Trieste, Italy), which utilizes specific 200-300 μm conically shaped micro-optical fibres with radial emission (ELX 200-300 Radial fibres), on eyelid dermal thickness. Ten patients underwent three laser sessions with high-frequency linear ultrasound imaging using the Esaote SL3116 probe to measure dermal changes at baseline, one month, and three months post-treatment. EndoliftX®, a minimally invasive laser procedure, delivers energy subdermally, promoting collagen remodeling and skin firming while preserving the epidermal integrity. The results indicated a consistent and significant increase in dermal thickness, demonstrating the potential of EndoliftX® as a valuable, non-surgical option for periorbital rejuvenation in oculoplastic practice. These findings underscore the importance of precise, non-invasive imaging techniques, such as the Esaote SL3116 probe, in objectively quantifying treatment outcomes.

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Ethics Approval

This study involved only non-invasive ultrasound evaluation of dermal thickness in patients undergoing eyelid treatment using the EndoliftX® clinical protocol, which is based on a 1470 nm diode laser. No tissue samples were collected, and no identifiable patient data were used. All procedures were carried out as part of routine clinical practice. Therefore, ethical committee approval was not required, in accordance with applicable research regulations. All participants provided informed consent to participate in this study.

CRediT authorship contribution

Gloria Misasi: clinical evaluation, data collection, manuscript draft; Roberto Ruffa: study design, ultrasound evaluation, manuscript review. All authors have read and approved the final version of the manuscript and agreed to be accountable for all aspects of the work.

Supporting Agencies

The manufacturer did not provide financial support for the study, except for covering the publication costs.

Data Availability Statement

All data underlying the findings of this study are available from the corresponding author upon reasonable request.

How to Cite



Misasi, G., & Ruffa, R. (2025). Evaluation of eyelid dermal thickening following EndoliftX® treatment with a 1470 nm diode laser: assessment using a high-frequency linear ultrasound probe. Laser Therapy, 32(2). https://doi.org/10.4081/ltj.2025.417
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