https://doi.org/10.4081/ltj.2023.326 Effective optical zone after corneal lenticule extraction with the CLEAR femtosecond laser application PDF Vol. 30 No. 2 (2023) Submitted: 10 September 2023 Accepted: 15 November 2023 Published: 23 November 2023 Myopia, LASIK, lenticule extraction, femtosecond laser, optical zone Abstract Views: 4288 PDF: 158 Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Authors Antonio Leccisotti leccisotti@libero.it Siena Eye Laser, Poggibonsi, Siena; Scuola di Specializzazione in Oftalmologia, Università di Siena, Italy. Stefania V. Fields Siena Eye Laser, Poggibonsi, Siena, Italy. Giuseppe De Bartolo https://orcid.org/0000-0002-6666-2440 Siena Eye Laser, Poggibonsi, Siena, Italy. Christian Crudale https://orcid.org/0009-0006-4002-1481 Siena Eye Laser, Poggibonsi, Siena, Italy. Abstract Laser vision correction of myopia induces an effective optical zone (EOZ) smaller than the programmed optical zone (POZ) by 16 to 26%. We evaluated the EOZ after corneal lenticule extraction for myopia with astigmatism ≤1 diopter (D) with a new femtosecond laser application (CLEAR), compared to POZ in a retrospective, consecutive, comparative case series study. Forty eyes of 40 patients underwent lenticule extraction with the Ziemer CLEAR® application; the control group was composed of 40 eyes of 40 patients receiving myopic femtosecond laser in situ keratomileusis (LASIK); EOZ was calculated on difference tangential maps at 6 months. For lenticule extraction, mean preoperative spherical equivalent (SE) was -6.03±2.48 D; mean POZ was 6.43±0.27 mm; EOZ 5.55±0.45 mm; mean difference between POZ and EOZ was 0.88 ± 0.28 mm (p=0.00); the mean reduction of EOZ compared to POZ was 13.60%±4.75; a positive correlation between preoperative SE and percent reduction of EOZ was found (r=0.63). For LASIK, mean preoperative SE was -5.89±2.14 D; mean POZ was 6.57±0.34 mm; EOZ 5.16±0.53 mm; the mean difference between POZ and EOZ was 1.41±0.35 mm (p=0.00); the mean reduction of EOZ compared to POZ was 21.46%±5.20. The mean difference between EOZ of the 2 procedures was 0.39 mm (p=0.0008). The mean difference between the reduction in optical zone (POZ-EOZ) of the 2 procedures was -0.53 (p=0.00). In conclusion, in myopia with low astigmatism, the CLEAR application for lenticule extraction provided a limited reduction in EOZ, compared with existing platforms. A positive correlation exists between corrected SE and reduction of the EOZ. 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DOI: https://doi.org/10.1007/s00417-020-04674-z Author Biography Antonio Leccisotti, Siena Eye Laser, Poggibonsi, Siena; Scuola di Specializzazione in Oftalmologia, Università di Siena School of Biomedical Sciences, Ulster University, Coleraine, UK Citation / Copyright How to Cite Leccisotti, A., Fields, S. V., De Bartolo, G., & Crudale, C. (2023). Effective optical zone after corneal lenticule extraction with the CLEAR femtosecond laser application. Laser Therapy, 30(2). https://doi.org/10.4081/ltj.2023.326 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Copyright (c) 2023 the Author(s) This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published. Similar Articles Ernest A. 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